个人介绍

胡晓春，副教授，44118太阳成城集团特聘研究员，44118太阳成城集团伟长学者（三级）。2019年9月毕业于同济大学，获博士学位。2020年1月至2022年12月在同济大学附属东方医院从事博士后研究工作，2022年12月进入44118太阳成城集团工作。以（共同）第一作者或（共同）通讯作者在ACS Nano, Adv. Sci., Acta Pharm. Sin. B, J. Control. Release等权威期刊上发表SCI论文20余篇。入选上海市“超级博士后”（2020），主持国家自然科学基金青年项目、中国博士后科学基金面上项目和军科委项目等。

主要研究方向

1. 多肽药物的开发及应用；

2. 生物相容性多功能纳米材料的开发及应用

代表性学术成果

论文（最具代表性）

[1] J. Wu, L. Wang, S. Jian, R. Ji, Y. Zuo, S. Liu, X. Hu*, H. Hu*, Logic-Gated Bioorthogonal In Situ Synthesis of Proteolysis-Targeting Chimeras for Precise Protein Degradation and Synergistic Immunotherapy, ACS Nano 2026, 10.1021/acsnano.6c04279.

[2] L. Wang, J. Wu, R. Ji, S. Qiang, Y. Shen, Y. Zuo, S. Jian, S. Liu, F. Xu*, H. Hu*, X. Hu*, A Spatiotemporally Controlled Nanoplatform for Photothermal BRD4 Degradation Enables Synergistic Cancer Immunotherapy, Adv. Sci. 2026, 13:e23928.

[3] J. Wu, R. Ji, L. Wang, Y. Zhu, S. Jian, Y. Zuo, S. Liu, Y. Shi, X. Hu*, H. Hu*, A Peptide-Based Nano-PROTAC Synergistically Driving Ferroptosis-Immunotherapy in Triple-Negative Breast Cancer, Acta Pharm. Sin. B 2026.

[4] N. Zhang^#, H. Shen^#, W. Cong, Y. Zhu, F. Xu*, X. Hu*, H. Hu, Dual-Stimuli-Responsive Nanoplatform Delivering Molecular Glue CR8 for Synergistic CDK12 Degradation and Immunomodulatory Photothermal Therapy in TNBC, ACS Appl. Mater. Interfaces 2026, 18, 11, 16945-16958.

[5] R. Ji, J. Wu, L. Wang, F. Xu, J. Hu, Y. Shi, S. Liu, F. Xu*, X. Hu*, H. Hu*, Targeted GPX4 Degradation Mediated by Hypoxia-Overcoming Nano-PDTACs for Synergistic Ferroptosis–Immunotherapy, Adv. Healthc. Mater. 2026; 15:e03869.

[6] N. Zhang^#, R. Li^#, H. Shen, H. Li, S. Liu, H. Liao, W. Cong*, X. Hu*, H. Hu*, Self-Assembled Molecular Glue Prodrug System for Enhanced Synergistic Tumor Therapy by Combining CDK12 Protein Degradation and Immunotherapy, ACS Appl. Mater. Interfaces 2025, 17, 26, 37435-37447.

[7] X. Hu^#, R. Li^#, W. Wu, K. Fang, Z. Zhu, Y. Wang, L. Zhou, M. Chen, C. Dong*, S. Shi*, A Fe(III)-porphyrin-oxaliplatin(IV) nanoplatform for enhanced ferroptosis and combined therapy, J. Control. Release 348 (2022) 660-671.

社会学术兼职

44118太阳成城集团附属411医院 特聘研究员

中华中医药学会中药化学分会青年委员

Scientific Reports编委

Cancer Lett.、Eur. J. Med. Chem.、Chem. Eng. J.等杂志审稿人