个人介绍
杨剑，44118太阳成城集团副教授。2017 年博士毕业于中国药科大学药物化学专业。2015—2017 年于哈佛44118太阳成城集团 / 麻省总院开展联合培养博士研究，2017 年 7 月至 2020 年 7 月在本校完成博士后研究，主要研究方向为分子影像学与化员工物学。以第一作者及合作作者在 PNAS、EJNMMI、Chemical Science、Journal of Medicinal Chemistry、Chemical Communications、ACS Chemical Neuroscience 等期刊发表 SCI 论文 40 余篇，获国际、国内专利各 1 项。多次受邀在国内外学术会议作报告，兼任《Nature Communications》《Bioorganic Chemistry》《Chemical Engineering Journal》等四十余种期刊审稿人。先后主持国家自然科学基金面上项目、上海市自然科学基金面上项目、上海市分子影像重点实验室开放基金、中国博士后基金及多项横向课题，参与国家自然科学基金青年项目。现担任《Frontiers in Bioengineering and Biotechnology》《Frontiers in Immunology》海外副主编，同时兼任上海市药学会、上海市医学会、中国老年医学学会等多个学会青年委员及科研评审专家。
主要研究领域
1. 神经退行性疾病早期诊断分子探针的研究；
2. 新型成像技术的开发；
3. 体外诊断试剂的开发与研究；
4. 新型核素药物的合成与发现。
代表性学术成果
论文（最具代表性）
1) Virtual Screening and Fragment Growth Strategy for Developing Near-Infrared Fluorescent Probes to Detect Aβ in Alzheimer’s Disease Model. Guanyu Xu, Can Zhou, Geng Su, Zeyin Liang, Jianyu Wu, Tiantian Tang, Yuemin Bian, Jian Ca, Yi Zou and Jian Yang*. European Journal of Medicinal Chemistry 292(2025)117695
2) Novel Dual-Functional Half-Curcumin Analogues as a Fluorescent and PET Probe for β‑Amyloid Imaging in the Alzheimer’s Disease APP/PS1 Model. Haijun Yang, Ke Li, Tingfang Wang, Yi Zou, Guanyu Xu, Can Zhou, Zeying Liang, Yingqiu Wang* Jianguo Lin*, and Jian Yang*. ACS Chemical Neuroscience. 2025, 16, 365-373.
3) Near-infrared II Theranostic Agents for the Diagnosis and Treatment of Alzheimer’s Disease. Can Zhou, Fantian Zeng, Haijun Yang, Zeying Liang, Guanyu Xu, Xiao Li, Xingdang, Liu, Jian Yang*. European Journal of Nuclear Medicine and Molecular Imaging. 51, 2953-2969 (2024).
4) Yiran Ge, Fantian Zeng, Gaofeng Su, Kewen Peng, Xiao Li, Huijuan Yu, Chao Cheng*, Yungen Xu*, and Jian Yang*. Curcumin Complex Analogues as Near-infrared Fluorescent Probe for monitoring all Aβ Species in Early Alzheimer’s Disease Model. ACS Chemical Neuroscience. 2021, 12, 19, 3683–3689.
5)Jian Yang#, Ran Cheng#, Hualong Fu, Jing Yang, Jie Lu, Yengen Xu, Steven H. Liang, Mengchao Cui, Chongzhao Ran. Half-curcuminoid analogues as PET imaging probes for Amyloid beta species. Chemical Communications, 2019. 55(25):3630-3633.
6)Jian Yang#, Xueli Zhang#, Peng Yuan#, Jing Yang, Yungen Xu, Jaime Grutzendler, Yihan Shao, Anna Moore, Chongzhao Ran. Oxalate-curcumin-based probe for micro- and macroimaging of reactive oxygen species in Alzheimer’s disease. Proceedings of the National Academy of Sciences, 2017, 114 (47) 12384-12389.
